Reactome | RAS GEFs [plasma membrane]

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RAS GEFs [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:5672963] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:5672602] Rothfels, Karen, 2015-02-05
dbId	5672601
displayName	RAS GEFs [plasma membrane]
hasMember	[Complex:R-HSA-5654264] Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5654275] Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5654287] Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5654296] Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5654316] Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-392045] Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] - Homo sapiens [Complex:R-HSA-1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - Homo sapiens [Complex:R-HSA-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Homo sapiens [Complex:R-HSA-1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] - Homo sapiens [Complex:R-HSA-109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] - Homo sapiens [Complex:R-HSA-2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] - Homo sapiens [Complex:R-HSA-186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] - Homo sapiens [Complex:R-HSA-210970] SOS-1 bound to Tie2:Grb2 [plasma membrane] - Homo sapiens [Complex:R-HSA-1168369] p-RASGRP1,3:DAG [plasma membrane] - Homo sapiens [Complex:R-HSA-205202] GRB2:SOS1:p-KIT complex [plasma membrane] - Homo sapiens [Complex:R-HSA-442735] Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] - Homo sapiens [Complex:R-HSA-921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-5685367] GRB2-1:SOS1:p-Y-SHC [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5672599] RAPGEF2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5672598] RASGEF1A [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-194944] RASGRF2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-870270] RASGRP1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2685600] RASGRP4 [cytosol] - Homo sapiens [Complex:R-HSA-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-8851897] HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-8851860] HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-8851807] HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-9607300] Active FLT3:GRB2:SOS1 [plasma membrane] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-5672601] RAS GEFs [plasma membrane] - Mus musculus [DefinedSet:R-RNO-5672601] RAS GEFs [plasma membrane] - Rattus norvegicus [DefinedSet:R-CFA-5672601] RAS GEFs [plasma membrane] - Canis familiaris [DefinedSet:R-BTA-5672601] RAS GEFs [plasma membrane] - Bos taurus [DefinedSet:R-SSC-5672601] RAS GEFs [plasma membrane] - Sus scrofa [DefinedSet:R-DRE-5672601] RAS GEFs [plasma membrane] - Danio rerio [DefinedSet:R-XTR-5672601] RAS GEFs [plasma membrane] - Xenopus tropicalis [DefinedSet:R-GGA-5672601] RAS GEFs [plasma membrane] - Gallus gallus [DefinedSet:R-DME-5672601] RAS GEFs [plasma membrane] - Drosophila melanogaster [DefinedSet:R-CEL-5672601] RAS GEFs [plasma membrane] - Caenorhabditis elegans [DefinedSet:R-DDI-5672601] RAS GEFs [plasma membrane] - Dictyostelium discoideum
maxDepth	11
modified	[InstanceEdit:9628702] Varusai, Thawfeek, 2018-11-12
name	RAS GEFs
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-5672601
updateTrackers	[UpdateTracker:9895397] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v59:[updateContainedMemberOrCandidate] [UpdateTracker:9898102] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v63:[updateContainedMemberOrCandidate] [UpdateTracker:9900874] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v70:[updateContainedMemberOrCandidate] [UpdateTracker:9900329] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v68:[updateContainedMemberOrCandidate] [UpdateTracker:9899483] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v66:[updateContainedMemberOrCandidate] [UpdateTracker:9897787] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v62:[updateContainedMemberOrCandidate] [UpdateTracker:9899885] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v67:[addCompartment, updateContainedMemberOrCandidate] [UpdateTracker:9894130] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v56:[addHasMember, updateContainedMemberOrCandidate] [UpdateTracker:9894960] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v58:[addHasMember] [UpdateTracker:9899169] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v65:[addHasMember] [UpdateTracker:9892808] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v54:[updateContainedMemberOrCandidate] [UpdateTracker:9894512] Update Tracker - [DefinedSet:5672601] RAS GEFs [plasma membrane] - v57:[updateContainedMemberOrCandidate]

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[CatalystActivity:5672963] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]

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