Reactome | RAS GEFs [plasma membrane]

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RAS GEFs [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10518658] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10518657
displayName	RAS GEFs [plasma membrane]
hasMember	[Complex:R-SSC-5654264] Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5654275] Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5654287] Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5654296] Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5654316] Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-392045] Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] - Sus scrofa [Complex:R-SSC-1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - Sus scrofa [Complex:R-SSC-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Sus scrofa [Complex:R-SSC-1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] - Sus scrofa [Complex:R-SSC-109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] - Sus scrofa [Complex:R-SSC-2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] - Sus scrofa [Complex:R-SSC-186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] - Sus scrofa [Complex:R-SSC-210970] SOS-1 bound to Tie2:Grb2 [plasma membrane] - Sus scrofa [Complex:R-SSC-1168369] p-RASGRP1,3:DAG [plasma membrane] - Sus scrofa [Complex:R-SSC-205202] GRB2:SOS1:p-KIT complex [plasma membrane] - Sus scrofa [Complex:R-SSC-442735] Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] - Sus scrofa [Complex:R-SSC-921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-5685367] GRB2-1:SOS1:p-Y-SHC [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-5672598] RASGEF1A [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-194944] RASGRF2 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-870270] RASGRP1 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-2685600] RASGRP4 [cytosol] - Sus scrofa [Complex:R-SSC-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-8851897] HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-8851860] HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-8851807] HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] - Sus scrofa [Complex:R-SSC-9607300] Active FLT3:GRB2:SOS1 [plasma membrane] - Sus scrofa
inDisease	false
inferredFrom	[DefinedSet:R-HSA-5672601] RAS GEFs [plasma membrane] - Homo sapiens
maxDepth	12
name	RAS GEFs
schemaClass	DefinedSet
species	[Species:49633] Sus scrofa
stId	R-SSC-5672601

Referrals

(physicalEntity)	[CatalystActivity:10518658] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
(inferredTo)	[DefinedSet:R-HSA-5672601] RAS GEFs [plasma membrane]

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