Reactome | RAS GEFs [plasma membrane]

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RAS GEFs [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10881287] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10881286
displayName	RAS GEFs [plasma membrane]
hasMember	[Complex:R-DME-5654264] Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5654275] Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5654287] Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5654296] Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5654316] Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-392045] Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] - Drosophila melanogaster [Complex:R-DME-1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] - Drosophila melanogaster [Complex:R-DME-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] - Drosophila melanogaster [Complex:R-DME-109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] - Drosophila melanogaster [Complex:R-DME-2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] - Drosophila melanogaster [Complex:R-DME-186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-210970] SOS-1 bound to Tie2:Grb2 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-205202] GRB2:SOS1:p-KIT complex [plasma membrane] - Drosophila melanogaster [Complex:R-DME-5685367] GRB2-1:SOS1:p-Y-SHC [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-DME-5672599] PDZ-GEF [cytosol] - Drosophila melanogaster [DefinedSet:R-DME-5672598-4] Homologues of RASGEF1A [cytosol] - Drosophila melanogaster [Complex:R-DME-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] - Drosophila melanogaster [Complex:R-DME-9607300] Active FLT3:GRB2:SOS1 [plasma membrane] - Drosophila melanogaster
inDisease	false
inferredFrom	[DefinedSet:R-HSA-5672601] RAS GEFs [plasma membrane] - Homo sapiens
maxDepth	11
name	RAS GEFs
schemaClass	DefinedSet
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5672601

Referrals

(physicalEntity)	[CatalystActivity:10881287] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
(inferredTo)	[DefinedSet:R-HSA-5672601] RAS GEFs [plasma membrane]

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