Reactome | Signaling by FGFR1 in disease

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Signaling by FGFR1 in disease Show undefined attributes

authored	[InstanceEdit:5649621] Rothfels, Karen, 2014-11-20
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12819429] BioModels Database:BIOMD0000000664 [DatabaseIdentifier:12020828] Mondo:0005497 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	5655302
deleted	[Deleted:6789863] Deletion of instance: 5655311
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Signaling by FGFR1 in disease
edited	[InstanceEdit:5655401] Rothfels, Karen, 2014-12-05
eventOf	[Pathway:R-HSA-1226099] Signaling by FGFR in disease - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation - Homo sapiens [Reaction:R-HSA-5655269] Activated FGFR1 mutants bind FRS2 - Homo sapiens [Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2 - Homo sapiens [Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens [Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens [Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-1839094] Activated FGFR1 mutants and fusions bind PLCG1 - Homo sapiens [Reaction:R-HSA-1839098] Activated FGFR1 mutants and fusions phosphorylate PLCG1 - Homo sapiens [Reaction:R-HSA-1839100] p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2021-12-08
literatureReference	[LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing [LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes [LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer [LiteratureReference:2023308] A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome [LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity [LiteratureReference:1614268] Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines [LiteratureReference:1614272] Somatic mutations of the protein kinase gene family in human lung cancer [LiteratureReference:1614246] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [LiteratureReference:1982006] 8p11 myeloproliferative syndrome: a review [LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer [LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
maxDepth	4
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Signaling by FGFR1 in disease
normalPathway	[Pathway:R-HSA-5654736] Signaling by FGFR1
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5655302
summation	[Summation:1982034] The FGFR1 gene has been shown to be subject to activating mu...
updateTrackers	[UpdateTracker:9783622] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v56:[addLiteratureReference, modifyText, updateContainedPathway] [UpdateTracker:9784649] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE] [UpdateTracker:9775334] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v79:[updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9783622] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v56:[addLiteratureReference, modifyText, updateContainedPathway] [UpdateTracker:9784649] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE] [UpdateTracker:9775334] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v79:[updateContainedRLE]
(replacementInstances)	[Deleted:6789863] Deletion of instance: 5655311
(hasEvent)	[Pathway:R-HSA-1226099] Signaling by FGFR in disease

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