Reactome | Activated FGFR1 mutants and fusions phosphorylate PLCG1

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Activated FGFR1 mutants and fusions phosphorylate PLCG1 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:1839099] protein tyrosine kinase activity of Activated FGFR1 mutants and fusions:PLCG1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1839097] Rothfels, K, 2011-10-27
dbId	1839098
disease	[Disease:1500689] cancer
displayName	Activated FGFR1 mutants and fusions phosphorylate PLCG1
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654444] gain_of_function of Activated FGFR1 mutants and fusions:PLCG1 [cytosol]
eventOf	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
followingEvent	[Reaction:R-HSA-1839100] p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions - Homo sapiens
input	[Complex:R-HSA-1839061] Activated FGFR1 mutants and fusions:PLCG1 [cytosol] 4 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:189824] Phospholipase C-gamma as a signal-transducing element
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR1 mutants and fusions phosphorylate PLCG1
normalReaction	[Reaction:R-HSA-5654149] Activated FGFR1 phosphorylates PLCG1
output	[Complex:R-HSA-1839062] Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol] 4 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-1839094] Activated FGFR1 mutants and fusions bind PLCG1 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1839098
summation	[Summation:2077386] By analogy with the wild-type pathway, PLC-gamma is presumed...

Referrals

(hasEvent)	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease
(precedingEvent)	[Reaction:R-HSA-1839100] p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions

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