Reactome | FRS-mediated FGFR4 signaling

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FRS-mediated FGFR4 signaling Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
created	[InstanceEdit:5654713] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	5654712
deleted	[Deleted:5655580] Deletion of instance: 190345
displayName	FRS-mediated FGFR4 signaling
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654716] Downstream signaling of activated FGFR4 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5654422] Activated FGFR4 binds FRS2 - Homo sapiens [Reaction:R-HSA-5654651] Activated FGFR4 binds FRS3 - Homo sapiens [Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2 - Homo sapiens [Reaction:R-HSA-5654653] Activated FGFR4 phosphorylates FRS3 - Homo sapiens [Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Homo sapiens [Reaction:R-HSA-5654655] Activated FGFR4 phosphorylates PPTN11 - Homo sapiens [Reaction:R-HSA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors [LiteratureReference:191015] Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways [LiteratureReference:191490] Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells [LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	FRS-mediated FGFR4 signaling
orthologousEvent	[Pathway:R-CEL-5654712] FRS-mediated FGFR4 signaling - Caenorhabditis elegans [Pathway:R-DME-5654712] FRS-mediated FGFR4 signaling - Drosophila melanogaster [Pathway:R-GGA-5654712] FRS-mediated FGFR4 signaling - Gallus gallus [Pathway:R-XTR-5654712] FRS-mediated FGFR4 signaling - Xenopus tropicalis [Pathway:R-DRE-5654712] FRS-mediated FGFR4 signaling - Danio rerio [Pathway:R-SSC-5654712] FRS-mediated FGFR4 signaling - Sus scrofa [Pathway:R-BTA-5654712] FRS-mediated FGFR4 signaling - Bos taurus [Pathway:R-CFA-5654712] FRS-mediated FGFR4 signaling - Canis familiaris [Pathway:R-RNO-5654712] FRS-mediated FGFR4 signaling - Rattus norvegicus [Pathway:R-MMU-5654712] FRS-mediated FGFR4 signaling - Mus musculus
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5654712
summation	[Summation:191017] The FRS family of scaffolding adaptor proteins has two membe...
updateTrackers	[UpdateTracker:9782946] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v58:[removeHasEvent] [UpdateTracker:9782550] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v59:[addHasEvent] [UpdateTracker:9784834] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v53:[add_removeHasEvent] [UpdateTracker:9783597] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v56:[updateContainedPathway]

Referrals

(updatedInstance)	[UpdateTracker:9782946] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v58:[removeHasEvent] [UpdateTracker:9782550] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v59:[addHasEvent] [UpdateTracker:9784834] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v53:[add_removeHasEvent] [UpdateTracker:9783597] Update Tracker - [Pathway:5654712] FRS-mediated FGFR4 signaling - v56:[updateContainedPathway]
(replacementInstances)	[Deleted:5655580] Deletion of instance: 190345
(hasEvent)	[Pathway:R-HSA-5654716] Downstream signaling of activated FGFR4

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