Reactome | FRS-mediated FGFR4 signaling

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FRS-mediated FGFR4 signaling Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224775
displayName	FRS-mediated FGFR4 signaling
eventOf	[Pathway:R-RNO-5654716] Downstream signaling of activated FGFR4 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-5654422] Activated FGFR4 binds FRS2 - Rattus norvegicus [Reaction:R-RNO-5654651] Activated FGFR4 binds FRS3 - Rattus norvegicus [Reaction:R-RNO-5654418] Activated FGFR4 phosphorylates FRS2 - Rattus norvegicus [Reaction:R-RNO-5654653] Activated FGFR4 phosphorylates FRS3 - Rattus norvegicus [Reaction:R-RNO-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Rattus norvegicus [Reaction:R-RNO-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Rattus norvegicus [Reaction:R-RNO-5654655] Activated FGFR4 phosphorylates PPTN11 - Rattus norvegicus [Reaction:R-RNO-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	FRS-mediated FGFR4 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5654712
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5654716] Downstream signaling of activated FGFR4
(inferredTo)	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling

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