Reactome | Activated FGFR4 phosphorylates FRS2

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Activated FGFR4 phosphorylates FRS2 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:5654419] protein tyrosine kinase activity of Activated FGFR4:FRS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5654421] Rothfels, Karen, 2014-12-03
dbId	5654418
deleted	[Deleted:5655568] Deletion of instance: 190353
diseaseReaction	[Reaction:R-HSA-5655284] Activated FGFR4 mutants phosphorylate FRS2 - Homo sapiens
displayName	Activated FGFR4 phosphorylates FRS2
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Homo sapiens [Reaction:R-HSA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
input	[Complex:R-HSA-5654182] Activated FGFR4:FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:532232] Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 [LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated FGFR4 phosphorylates FRS2
orthologousEvent	[Reaction:R-CFA-5654418] Activated FGFR4 phosphorylates FRS2 - Canis familiaris [Reaction:R-CEL-5654418] Activated FGFR4 phosphorylates FRS2 - Caenorhabditis elegans [Reaction:R-DME-5654418] Activated FGFR4 phosphorylates FRS2 - Drosophila melanogaster [Reaction:R-GGA-5654418] Activated FGFR4 phosphorylates FRS2 - Gallus gallus [Reaction:R-XTR-5654418] Activated FGFR4 phosphorylates FRS2 - Xenopus tropicalis [Reaction:R-DRE-5654418] Activated FGFR4 phosphorylates FRS2 - Danio rerio [Reaction:R-SSC-5654418] Activated FGFR4 phosphorylates FRS2 - Sus scrofa [Reaction:R-BTA-5654418] Activated FGFR4 phosphorylates FRS2 - Bos taurus [Reaction:R-RNO-5654418] Activated FGFR4 phosphorylates FRS2 - Rattus norvegicus [Reaction:R-MMU-5654418] Activated FGFR4 phosphorylates FRS2 - Mus musculus
output	[Complex:R-HSA-5654193] Activated FGFR4:p-FRS2 [plasma membrane] 6 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-5654422] Activated FGFR4 binds FRS2 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5654420] Negative regulation by 'Activated FGFR4:p-8T-FRS2 [plasma membrane]'
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654418
summation	[Summation:191507] FRS2 (also known as FRS alpha is activated through tyrosine...

Referrals

(replacementInstances)	[Deleted:5655568] Deletion of instance: 190353
(normalReaction)	[Reaction:R-HSA-5655284] Activated FGFR4 mutants phosphorylate FRS2
(hasEvent)	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)	[Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 [Reaction:R-HSA-5654658] Activated FGFR4:p-FRS bind to PPTN11 [Reaction:R-HSA-5654659] Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1

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