Reactome | Activated FGFR4 phosphorylates PPTN11

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Activated FGFR4 phosphorylates PPTN11 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:5654657] protein tyrosine kinase activity of Activated FGFR4:p-FRS:PTPN11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:5654656] Rothfels, Karen, 2014-12-03
dbId	5654655
deleted	[Deleted:5655563] Deletion of instance: 190362
displayName	Activated FGFR4 phosphorylates PPTN11
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 - Homo sapiens [Reaction:R-HSA-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Homo sapiens
input	[Complex:R-HSA-5654337] Activated FGFR4:p-FRS:PTPN11 [plasma membrane] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling [LiteratureReference:1268085] SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated FGFR4 phosphorylates PPTN11
orthologousEvent	[Reaction:R-BTA-5654655] Activated FGFR4 phosphorylates PPTN11 - Bos taurus [Reaction:R-DME-5654655] Activated FGFR4 phosphorylates PPTN11 - Drosophila melanogaster [Reaction:R-GGA-5654655] Activated FGFR4 phosphorylates PPTN11 - Gallus gallus [Reaction:R-XTR-5654655] Activated FGFR4 phosphorylates PPTN11 - Xenopus tropicalis [Reaction:R-DRE-5654655] Activated FGFR4 phosphorylates PPTN11 - Danio rerio [Reaction:R-SSC-5654655] Activated FGFR4 phosphorylates PPTN11 - Sus scrofa [Reaction:R-CFA-5654655] Activated FGFR4 phosphorylates PPTN11 - Canis familiaris [Reaction:R-RNO-5654655] Activated FGFR4 phosphorylates PPTN11 - Rattus norvegicus [Reaction:R-MMU-5654655] Activated FGFR4 phosphorylates PPTN11 - Mus musculus
output	[Complex:R-HSA-5654339] Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35 [InstanceEdit:1549563] Gotoh, N, 2011-08-26
revised	[InstanceEdit:1493881] Rothfels, K, 2011-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654655
summation	[Summation:191517] Tyrosine phosphorylation of PPTN11/SHP2 by FGFR kinase is re...

Referrals

(replacementInstances)	[Deleted:5655563] Deletion of instance: 190362
(hasEvent)	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)	[Reaction:R-HSA-5654734] p-CBL:GRB2 binds p-FRS2:activated FGFR4 [Reaction:R-HSA-5654667] Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1