Reactome | Activated FGFR4:p-FRS binds GRB2:SOS1

Activated FGFR4:p-FRS binds GRB2:SOS1

Stable Identifier

R-HSA-5654664

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR4 (Homo sapiens)
      - Downstream signaling of activated FGFR4 (Homo sapiens)
        
        FRS-mediated FGFR4 signaling (Homo sapiens)
        
        Activated FGFR4:p-FRS binds GRB2:SOS1 (Homo sapiens)

General

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Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:PPTN11.

Literature References

PubMed ID	Title	Journal	Year
9182757	A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway Kouhara, H, Hadari, YR, Spivak-Kroizman, T, Schilling, J, Bar-Sagi, D, Lax, I, Schlessinger, J	Cell	1997
7559490	Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells Klint, P, Kanda, S, Claesson-Welsh, L	J Biol Chem	1995
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Hadari, YR, Gotoh, N, Guy, GR, Schlessinger, J, Lax, I	Proc Natl Acad Sci U S A	2001
11447289	Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways Hadari, YR, Gotoh, N, Kouhara, H, Lax, I, Schlessinger, J	Proc Natl Acad Sci U S A	2001
8780727	Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 Ong, SH, Goh, KC, Lim, YP, Low, BC, Klint, P, Claesson-Welsh, L, Cao, X, Tan, YH, Guy, GR	Biochem Biophys Res Commun	1996