Reactome | Activated FGFR4:p-FRS binds GRB2:SOS1

Schema > Reaction > Entries

Activated FGFR4:p-FRS binds GRB2:SOS1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10291714
displayName	Activated FGFR4:p-FRS binds GRB2:SOS1
eventOf	[Pathway:R-CFA-5654712] FRS-mediated FGFR4 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Canis familiaris [Reaction:R-CFA-5672965] RAS GEFs promote RAS nucleotide exchange - Canis familiaris
inferredFrom	[Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Homo sapiens
input	[DefinedSet:R-CFA-5654324] Activated FGFR4:p-FRS [plasma membrane] [Complex:R-CFA-109797] GRB2-1:SOS1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated FGFR4:p-FRS binds GRB2:SOS1
output	[Complex:R-CFA-5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-CFA-5654418] Activated FGFR4 phosphorylates FRS2 - Canis familiaris [Reaction:R-CFA-5654653] Activated FGFR4 phosphorylates FRS3 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5654664
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)	[Reaction:R-CFA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-CFA-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1