Tyrosine residue Y992 (corresponding to Y1016 when counting ...

created [InstanceEdit:5637772] Orlic-Milacic, Marija, 2014-11-12
dbId 5637771
displayName Tyrosine residue Y992 (corresponding to Y1016 when counting ...
schemaClass Summation
text Tyrosine residue Y992 (corresponding to Y1016 when counting from the first amino acid of the EGFR precursor, prior to cleavage of the 24-amino acid signal peptide at the N-terminus), a docking site for PLC-gamma 1 (PLCG1), is phosphorylated in EGFRvIII cancer mutant and expected to recruit PLC-gamma 1 in the same way as the wild-type EGFR receptor (Grandal et al. 2007).
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