Reactome | p-5Y-EGFRvIII:PLCG1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:5637709] protein tyrosine kinase activity of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant - Homo sapiens
created	[InstanceEdit:5637699] Orlic-Milacic, Marija, 2014-11-12
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	5637698
disease	[Disease:1500689] cancer
displayName	p-5Y-EGFRvIII:PLCG1 [plasma membrane]
hasComponent	[Complex:R-HSA-1248654] p-5Y-EGFRvIII mutant dimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-167682] PLCG1 [plasma membrane]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	5
name	p-5Y-EGFRvIII:PLCG1
producedByEvent	[Reaction:R-HSA-5637792] PLC-gamma 1 binds to p-EGFRvIII mutant - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5637698

(output)	[Reaction:R-HSA-5637792] PLC-gamma 1 binds to p-EGFRvIII mutant
(input)	[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
(diseaseEntity)	[EntityFunctionalStatus:9630162] gain_of_function of p-5Y-EGFRvIII:PLCG1 [plasma membrane]
(physicalEntity)	[CatalystActivity:5637709] protein tyrosine kinase activity of p-5Y-EGFRvIII:PLCG1 [plasma membrane]

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