PLC-gamma 1 binds to p-EGFRvIII mutant

Stable Identifier
R-HSA-5637792
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Tyrosine residue Y992 (corresponding to Y1016 when counting from the first amino acid of the EGFR precursor, prior to cleavage of the 24-amino acid signal peptide at the N-terminus), a docking site for PLC-gamma 1 (PLCG1), is phosphorylated in EGFRvIII cancer mutant and expected to recruit PLC-gamma 1 in the same way as the wild-type EGFR receptor (Grandal et al. 2007).

Literature References
PubMed ID Title Journal Year
17372273 EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

Grandal, MV, Zandi, R, Pedersen, MW, Willumsen, BM, van Deurs, B, Poulsen, HS

Carcinogenesis 2007
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed