Reactome | FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein

FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein

Stable Identifier

R-HSA-5618073

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein

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Mass spectrometry analysis showed that FKBP51 (FKBP5) and FKBP52 (FKBP4) form analogous complexes with GR:HSP90:STIP1:HSP70:ATP (Ebong IO et al. 2016). Without hormone, FKBP51 is the major immunophilin in GR:HSP90 complexes, whereas after hormone treatment, FKBP52 rapidly replaces FKBP51 (Davies et al., 2002).

Literature References

PubMed ID	Title	Journal	Year
27462449	The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes Ebong, IO, Beilsten-Edmands, V, Patel, NA, Morgner, N, Robinson, CV	Cell Discov	2016
11751894	A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins Davies, TH, Ning, YM, Sánchez, ER	J. Biol. Chem.	2002