Reactome | FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein

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FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10178735
displayName	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
eventOf	[Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) - Rattus norvegicus [Reaction:R-RNO-9725885] P4 bind PGR (in the HSP90 chaperone complex) - Rattus norvegicus [Reaction:R-RNO-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-5618108] Fkbp4 [cytosol] [Complex:R-RNO-5618074] HSP90:ATP:FKBP5:PTGES3:nascent protein: [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein
output	[EntityWithAccessionedSequence:R-RNO-5618096] FKBP5 [cytosol] [Complex:R-RNO-5618101] HSP90:ATP:FKBP4:PTGES3:nascent protein: [cytosol]
precedingEvent	[Reaction:R-RNO-5618098] p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein - Rattus norvegicus
regulatedBy	[PositiveRegulation:R-HSA-5618100] Positive regulation by 'SH [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5618073
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-RNO-9690534] NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex) [Reaction:R-RNO-9725885] P4 bind PGR (in the HSP90 chaperone complex) [Reaction:R-RNO-5618099] NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)
(inferredTo)	[Reaction:R-HSA-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein