Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis

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Activation of anterior HOX genes in hindbrain development during early embryogenesis Show undefined attributes

authored	[InstanceEdit:5617432] May, Bruce, 2014-08-07 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
created	[InstanceEdit:5617463] May, Bruce, 2014-08-08
dbId	5617472
displayName	Activation of anterior HOX genes in hindbrain development during early embryogenesis
doi	10.3180/r-hsa-5617472.1
edited	[InstanceEdit:5617432] May, Bruce, 2014-08-07
eventOf	[Pathway:R-HSA-5619507] Activation of HOX genes during differentiation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:564] embryo development
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-5617431] Retinoic acid activates HOXA1 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5617471] HOXA1 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617458] HOXA1 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-5617452] Retinoic acid activates HOXB1 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5693644] HOXB1 maintains activation of HOXB1 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5617454] HOXB1 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617457] HOXB1 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-5617445] HOXD1 chromatin is activated - Homo sapiens [BlackBoxEvent:R-HSA-5617462] HOXD1 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617446] HOXD1 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-6810139] HOXA2 chromatin is activated - Homo sapiens [BlackBoxEvent:R-HSA-5617484] EGR2 (KROX20) activates HOXA2 expression - Homo sapiens [BlackBoxEvent:R-HSA-5621010] HOXB1 activates HOXA2 expression - Homo sapiens [BlackBoxEvent:R-HSA-5617483] HOXA2 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617479] HOXA2 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-6810159] HOXB2 chromatin is activated - Homo sapiens [BlackBoxEvent:R-HSA-5617492] EGR2 (KROX20) activates HOXB2 expression - Homo sapiens [BlackBoxEvent:R-HSA-5621002] HOXB1 activates HOXB2 expression - Homo sapiens [BlackBoxEvent:R-HSA-5617486] HOXB2 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617485] HOXB2 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-6810161] HOXA3 chromatin is activated - Homo sapiens [BlackBoxEvent:R-HSA-5617641] MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression - Homo sapiens [BlackBoxEvent:R-HSA-5617676] HOXA3 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617643] HOXA3 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-6810158] HOXB3 chromatin is activated - Homo sapiens [BlackBoxEvent:R-HSA-5617661] MAFB:JUN and EGR2 activate HOXB3 expression - Homo sapiens [BlackBoxEvent:R-HSA-5617672] HOXB3 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617668] HOXB3 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-5617650] HOXD3 chromatin is activated - Homo sapiens [BlackBoxEvent:R-HSA-5617642] HOXD3 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617652] HOXD3 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-5617862] Retinoic acid activates HOXA4 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5617877] HOXA4 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617879] HOXA4 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-5617859] Retinoic acid activates HOXB4 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5617867] HOXB4 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617881] HOXB4 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-5617887] HOXC4 chromatin is activated - Homo sapiens [BlackBoxEvent:R-HSA-5617866] HOXC4 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617855] HOXC4 mRNA is translated - Homo sapiens [BlackBoxEvent:R-HSA-5617896] Retinoic acid activates HOXD4 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5617874] HOXD4 gene is transcribed - Homo sapiens [BlackBoxEvent:R-HSA-5617864] HOXD4 mRNA is translated - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:5619505] Hox genes and segmentation of the vertebrate hindbrain [LiteratureReference:5619504] Hox genes and segmentation of the hindbrain and axial skeleton [LiteratureReference:5660989] Epigenetic regulation of vertebrate Hox genes: a dynamic equilibrium [LiteratureReference:5660987] SnapShot: Hox gene regulation [LiteratureReference:5660986] Hox genes and regional patterning of the vertebrate body plan [LiteratureReference:5687916] How degrading: Cyp26s in hindbrain development [LiteratureReference:5687929] Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse [LiteratureReference:5687931] Initiation, establishment and maintenance of Hox gene expression patterns in the mouse [LiteratureReference:5687961] Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation [LiteratureReference:5687926] Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family [LiteratureReference:5688581] Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development [LiteratureReference:5688610] HOXB1 founder mutation in humans recapitulates the phenotype of Hoxb1-/- mice [LiteratureReference:5688576] The clinical spectrum of homozygous HOXA1 mutations [LiteratureReference:5688611] A mutation in HOXA2 is responsible for autosomal-recessive microtia in an Iranian family [LiteratureReference:5690288] Retinoids induce stem cell differentiation via epigenetic changes [LiteratureReference:5690290] Role of retinoic acid in the differentiation of embryonal carcinoma and embryonic stem cells [LiteratureReference:6810192] Mechanisms of retinoic acid signalling and its roles in organ and limb development [LiteratureReference:5690503] Cellular and molecular insights into Hox protein action [LiteratureReference:6810191] Non-transcriptional interactions of Hox proteins: inventory, facts, and future directions
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Activation of anterior HOX genes in hindbrain development during early embryogenesis
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5617472
summation	[Summation:5617858] In mammals, anterior Hox genes may be defined as paralog gro...
updateTrackers	[UpdateTracker:9776036] Update Tracker - [Pathway:5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis - v78:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5619507] Activation of HOX genes during differentiation
(hasEncapsulatedEvent)	[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes
(updatedInstance)	[UpdateTracker:9776036] Update Tracker - [Pathway:5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis - v78:[updateContainedRLE]

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