Reactome | HOXB2 chromatin is activated

Schema > BlackBoxEvent > Entries

HOXB2 chromatin is activated Show undefined attributes

authored	[InstanceEdit:5617432] May, Bruce, 2014-08-07 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6810152] May, Bruce, 2015-11-15
dbId	6810159
displayName	HOXB2 chromatin is activated
edited	[InstanceEdit:6810149] May, Bruce, 2015-11-15
eventOf	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5617492] EGR2 (KROX20) activates HOXB2 expression - Homo sapiens [BlackBoxEvent:R-HSA-5621002] HOXB1 activates HOXB2 expression - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-6810170] Hoxb2 chromatin is activated - Mus musculus
input	[Complex:R-HSA-5617482] HOXB2 bivalent chromatin [nucleoplasm] [DefinedSet:R-HSA-5619379] MLL3,4 complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4687099] A histone H3 lysine 27 demethylase regulates animal posterior development [LiteratureReference:4687095] Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HOXB2 chromatin is activated
output	[Complex:R-HSA-6810166] HOXB2 active chromatin [nucleoplasm] [Complex:R-HSA-212285] PRC2 (EZH2) Core [nucleoplasm]
regulatedBy	[PositiveRegulation:R-HSA-6810167] Positive regulation by 'atRA [nucleoplasm]'
regulationReference	[RegulationReference:9642111] Positive regulation by 'atRA [nucleoplasm]' A histone H3 lysine 27 demethylase regulates animal posterior development
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6810159
summation	[Summation:6810156] During activation of HOXB1 by retinoic acid in human embryon...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-5621002] HOXB1 activates HOXB2 expression [BlackBoxEvent:R-HSA-5617492] EGR2 (KROX20) activates HOXB2 expression
(hasEvent)	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis
(inferredTo)	[BlackBoxEvent:R-MMU-6810170] Hoxb2 chromatin is activated