Reactome | HOXA2 chromatin is activated

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HOXA2 chromatin is activated Show undefined attributes

authored	[InstanceEdit:5617432] May, Bruce, 2014-08-07 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6810140] May, Bruce, 2015-11-15
dbId	6810139
displayName	HOXA2 chromatin is activated
edited	[InstanceEdit:6808659] May, Bruce, 2015-11-08
eventOf	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5617484] EGR2 (KROX20) activates HOXA2 expression - Homo sapiens [BlackBoxEvent:R-HSA-5621010] HOXB1 activates HOXA2 expression - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-6810138] Hoxa2 chromatin is activated - Mus musculus
input	[Complex:R-HSA-5617490] HOXA2 bivalent chromatin [nucleoplasm] [DefinedSet:R-HSA-5619379] MLL3,4 complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5620950] Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster [LiteratureReference:4687095] Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination [LiteratureReference:5620939] Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation [LiteratureReference:5626795] Hox in motion: tracking HoxA cluster conformation during differentiation [LiteratureReference:6810116] Structure, function and evolution of topologically associating domains (TADs) at HOX loci
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HOXA2 chromatin is activated
output	[Complex:R-HSA-6810133] HOXA2 active chromatin [nucleoplasm] [Complex:R-HSA-212285] PRC2 (EZH2) Core [nucleoplasm]
regulatedBy	[PositiveRegulation:R-HSA-6810153] Positive regulation by 'atRA [nucleoplasm]'
regulationReference	[RegulationReference:9642847] Positive regulation by 'atRA [nucleoplasm]' Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6810139
summation	[Summation:6810095] In human cell lines and tissues activation of HOXA2 chromati...

Referrals

(hasEvent)	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis
(precedingEvent)	[BlackBoxEvent:R-HSA-5617484] EGR2 (KROX20) activates HOXA2 expression [BlackBoxEvent:R-HSA-5621010] HOXB1 activates HOXA2 expression
(inferredTo)	[BlackBoxEvent:R-MMU-6810138] Hoxa2 chromatin is activated