Reactome | Retinoic acid activates HOXB1 chromatin

Schema > BlackBoxEvent > Entries

Retinoic acid activates HOXB1 chromatin Show undefined attributes

authored	[InstanceEdit:5617432] May, Bruce, 2014-08-07 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5617463] May, Bruce, 2014-08-08
dbId	5617452
displayName	Retinoic acid activates HOXB1 chromatin
edited	[InstanceEdit:5617425] May, Bruce, 2014-08-01
eventOf	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5693644] HOXB1 maintains activation of HOXB1 chromatin - Homo sapiens [BlackBoxEvent:R-HSA-5617454] HOXB1 gene is transcribed - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-5617960] Retinoic acid activates Hoxb1 chromatin - Mus musculus
input	[SimpleEntity:R-ALL-5334804] atRA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [DefinedSet:R-HSA-5619379] MLL3,4 complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442488] NCOA3 [nucleoplasm] [Complex:R-HSA-5617474] RARA,G:RXRA at HOXB1 bivalent chromatin [nucleoplasm] [Complex:R-HSA-209680] RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:4687075] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development [LiteratureReference:4687099] A histone H3 lysine 27 demethylase regulates animal posterior development [LiteratureReference:4687095] Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination [LiteratureReference:5617918] Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex [LiteratureReference:5690513] Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Retinoic acid activates HOXB1 chromatin
output	[Complex:R-HSA-5617470] atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442501] NCOR1 [nucleoplasm] [Complex:R-HSA-212285] PRC2 (EZH2) Core [nucleoplasm]
regulatedBy	[PositiveRegulation:R-HSA-6810142] Positive regulation by 'HOXA1 [nucleoplasm]'
regulationReference	[RegulationReference:9642943] Positive regulation by 'HOXA1 [nucleoplasm]' Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5617452
summation	[Summation:5617931] As inferred from mouse embryos and cell lines, retinoic acid... [Summation:6810086] As inferred from mouse embryos, HOXA1 acts synergistically w...

Referrals

(hasEvent)	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis
(precedingEvent)	[BlackBoxEvent:R-HSA-5693644] HOXB1 maintains activation of HOXB1 chromatin [BlackBoxEvent:R-HSA-5617454] HOXB1 gene is transcribed
(inferredTo)	[BlackBoxEvent:R-MMU-5617960] Retinoic acid activates Hoxb1 chromatin

Cite Us!