Reactome | Retinoic acid activates HOXA4 chromatin

Schema > BlackBoxEvent > Entries

Retinoic acid activates HOXA4 chromatin Show undefined attributes

authored	[InstanceEdit:5617432] May, Bruce, 2014-08-07 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5617850] May, Bruce, 2014-08-15
dbId	5617862
displayName	Retinoic acid activates HOXA4 chromatin
edited	[InstanceEdit:5617678] May, Bruce, 2014-08-13
eventOf	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5617877] HOXA4 gene is transcribed - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-5619434] Retinoic acid activates Hoxa4 chromatin - Mus musculus
input	[SimpleEntity:R-ALL-5334804] atRA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442488] NCOA3 [nucleoplasm] [Complex:R-HSA-5617876] RARA,B:RXRA at HOXA4 bivalent chromatin [nucleoplasm] [Complex:R-HSA-209680] RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5619159] Functional interaction between a RARE and an AP-2 binding site in the regulation of the human HOX A4 gene promoter [LiteratureReference:4687099] A histone H3 lysine 27 demethylase regulates animal posterior development [LiteratureReference:5620950] Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster [LiteratureReference:5626795] Hox in motion: tracking HoxA cluster conformation during differentiation [LiteratureReference:5624425] CTCF Controls HOXA Cluster Silencing and Mediates PRC2-Repressive Higher-Order Chromatin Structure in NT2/D1 Cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Retinoic acid activates HOXA4 chromatin
output	[Complex:R-HSA-5617873] atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442501] NCOR1 [nucleoplasm] [Complex:R-HSA-212285] PRC2 (EZH2) Core [nucleoplasm]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5617862
summation	[Summation:5617883] As inferred from mouse embryos, retinoic acid initially acti...

Referrals

(hasEvent)	[Pathway:R-HSA-5617472] Activation of anterior HOX genes in hindbrain development during early embryogenesis
(precedingEvent)	[BlackBoxEvent:R-HSA-5617877] HOXA4 gene is transcribed
(inferredTo)	[BlackBoxEvent:R-MMU-5619434] Retinoic acid activates Hoxa4 chromatin