Reactome | PKA phosphorylates GLI1

Schema > Reaction > Entries

PKA phosphorylates GLI1 Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:5610634] cAMP-dependent protein kinase activity of PKA catalytic subunit [ciliary base]
category	transition
compartment	[Compartment:5263232] ciliary base
created	[InstanceEdit:5610739] Rothfels, Karen, 2014-07-22
dbId	5610741
displayName	PKA phosphorylates GLI1
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome - Homo sapiens
followingEvent	[Reaction:R-HSA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Homo sapiens [Reaction:R-HSA-5610737] NUMB:ITCH bind and ubiquitnate GLI1 - Homo sapiens
inferredFrom	[Reaction:R-NUL-5610740] Pka phosphorylates GLI1 - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5610531] GLI1:SUFU [ciliary base]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:5609710] Dual degradation signals control Gli protein stability and tumor formation [LiteratureReference:208141] Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP [LiteratureReference:5609688] A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome [LiteratureReference:5609832] Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PKA phosphorylates GLI1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5610605] pS-GLI1:SUFU [ciliary base]
precedingEvent	[Reaction:R-HSA-5610749] cAMP dissociates PKA, promoting GLI processing - Homo sapiens [BlackBoxEvent:R-HSA-5610766] The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5610741
summation	[Summation:5610649] Although direct phosphorylation of GLI1 by PKA has not been ...

Referrals

(precedingEvent)	[Reaction:R-HSA-5610737] NUMB:ITCH bind and ubiquitnate GLI1 [Reaction:R-HSA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1
(hasEvent)	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome
(inferredTo)	[Reaction:R-NUL-5610740] Pka phosphorylates GLI1