Reactome | SCF(beta-TrCP) ubiquitinates p-GLI1

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SCF(beta-TrCP) ubiquitinates p-GLI1 Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:208937] ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
category	transition
compartment	[Compartment:5263232] ciliary base
created	[InstanceEdit:5610743] Rothfels, Karen, 2014-07-22
dbId	5610742
displayName	SCF(beta-TrCP) ubiquitinates p-GLI1
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Homo sapiens
input	[Complex:R-HSA-5610605] pS-GLI1:SUFU [ciliary base] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609710] Dual degradation signals control Gli protein stability and tumor formation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SCF(beta-TrCP) ubiquitinates p-GLI1
orthologousEvent	[Reaction:R-DME-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Drosophila melanogaster [Reaction:R-GGA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Gallus gallus [Reaction:R-XTR-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Xenopus tropicalis [Reaction:R-DRE-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Danio rerio [Reaction:R-BTA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Bos taurus [Reaction:R-CFA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Canis familiaris [Reaction:R-RNO-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Rattus norvegicus [Reaction:R-MMU-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Mus musculus
output	[Complex:R-HSA-5610612] ub-pS-GLI1:SUFU [ciliary base]
precedingEvent	[Reaction:R-HSA-5610741] PKA phosphorylates GLI1 - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5610742
summation	[Summation:5610660] GLI1 protein is degraded by the proteasome in the absence of...

Referrals

(hasEvent)	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome
(precedingEvent)	[BlackBoxEvent:R-HSA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

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