Reactome | GLI1 is degraded by the proteasome after ubiquitination by ITCH

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GLI1 is degraded by the proteasome after ubiquitination by ITCH Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5610761] Rothfels, Karen, 2014-07-22
dbId	5610760
displayName	GLI1 is degraded by the proteasome after ubiquitination by ITCH
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome - Homo sapiens
input	[Complex:R-HSA-5610565] NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609710] Dual degradation signals control Gli protein stability and tumor formation [LiteratureReference:5609824] Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination [LiteratureReference:5609813] Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GLI1 is degraded by the proteasome after ubiquitination by ITCH
orthologousEvent	[BlackBoxEvent:R-GGA-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Gallus gallus [BlackBoxEvent:R-XTR-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Xenopus tropicalis [BlackBoxEvent:R-DRE-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Danio rerio [BlackBoxEvent:R-SSC-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Sus scrofa [BlackBoxEvent:R-BTA-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Bos taurus [BlackBoxEvent:R-CFA-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Canis familiaris [BlackBoxEvent:R-RNO-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Rattus norvegicus [BlackBoxEvent:R-MMU-5610760] GLI1 is degraded by the proteasome after ubiquitination by ITCH - Mus musculus
output	[Complex:R-HSA-5610562] NUMB:ITCH [cytosol] [EntityWithAccessionedSequence:R-HSA-445455] SUFU [cytosol]
precedingEvent	[Reaction:R-HSA-5610737] NUMB:ITCH bind and ubiquitnate GLI1 - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5610760
summation	[Summation:5610673] In the absence of Hh signal, GLI1 is degraded by the proteas...

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[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome