Reactome | GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP

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GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP Show undefined attributes

authored	[InstanceEdit:5422974] Rothfels, Karen, 2014-05-07
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5610759] Rothfels, Karen, 2014-07-22
dbId	5610758
displayName	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
edited	[InstanceEdit:5617330] Gillespie, Marc E, 2014-07-25
eventOf	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome - Homo sapiens
input	[Complex:R-HSA-5610612] ub-pS-GLI1:SUFU [ciliary base]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5609710] Dual degradation signals control Gli protein stability and tumor formation [LiteratureReference:5609824] Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination [LiteratureReference:5609813] Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
orthologousEvent	[BlackBoxEvent:R-DME-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Drosophila melanogaster [BlackBoxEvent:R-GGA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Gallus gallus [BlackBoxEvent:R-XTR-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Xenopus tropicalis [BlackBoxEvent:R-DRE-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Danio rerio [BlackBoxEvent:R-SSC-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Sus scrofa [BlackBoxEvent:R-BTA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Bos taurus [BlackBoxEvent:R-CFA-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Canis familiaris [BlackBoxEvent:R-RNO-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Rattus norvegicus [BlackBoxEvent:R-MMU-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-445455] SUFU [cytosol]
precedingEvent	[Reaction:R-HSA-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Homo sapiens
releaseDate	2014-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5617331] Liu, Yulu Cherry, 2014-08-01
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5610758
summation	[Summation:5610673] In the absence of Hh signal, GLI1 is degraded by the proteas...

Referrals

(hasEvent)

[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome