Reactome | Degradation of GLI1 by the proteasome

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912786
displayName	Degradation of GLI1 by the proteasome
eventOf	[Pathway:R-DME-5610787] Hedgehog 'off' state - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-5610742] SCF(beta-TrCP) ubiquitinates p-GLI1 - Drosophila melanogaster [BlackBoxEvent:R-DME-5610758] GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Degradation of GLI1 by the proteasome
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5610780
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-5610787] Hedgehog 'off' state
(inferredTo)	[Pathway:R-HSA-5610780] Degradation of GLI1 by the proteasome

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