Reactome | OS9/ERLEC1 [endoplasmic reticulum quality control compartment]

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OS9/ERLEC1 [endoplasmic reticulum quality control compartment] Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:927893] endoplasmic reticulum quality control compartment
componentOf	[Complex:R-HSA-5362409] C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] - Homo sapiens [Complex:R-HSA-5362408] ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] - Homo sapiens [Complex:R-HSA-8866531] ERAD complex [endoplasmic reticulum membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5362450] Hh processing variants bind lectins - Homo sapiens [Reaction:R-HSA-5362437] C-terminal Hh fragments are bound by lectins - Homo sapiens
created	[InstanceEdit:5362376] Rothfels, Karen, 2014-04-15
dbId	5362377
displayName	OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
hasMember	[EntityWithAccessionedSequence:R-HSA-5362354] ERLEC1 [endoplasmic reticulum quality control compartment] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1022132] OS9 [endoplasmic reticulum membrane] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Mus musculus [DefinedSet:R-RNO-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Rattus norvegicus [DefinedSet:R-CFA-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Canis familiaris [DefinedSet:R-BTA-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Bos taurus [DefinedSet:R-SSC-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Sus scrofa [DefinedSet:R-DRE-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Danio rerio [DefinedSet:R-XTR-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-5362354] ERLEC1 [endoplasmic reticulum quality control compartment] - Gallus gallus [EntityWithAccessionedSequence:R-DME-5362354] Dmel\CG6766 [endoplasmic reticulum quality control compartment] - Drosophila melanogaster [DefinedSet:R-CEL-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Caenorhabditis elegans [DefinedSet:R-DDI-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Dictyostelium discoideum [DefinedSet:R-SPO-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - Schizosaccharomyces pombe
maxDepth	2
modified	[InstanceEdit:9628575] Rothfels, Karen, 2018-11-09
name	OS9/ERLEC1
producedByEvent	[Reaction:R-HSA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Homo sapiens [Reaction:R-HSA-5387389] Hh processing variants are translocated to the cytosol in a VCP-dependent manner - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-5362377
updateTrackers	[UpdateTracker:9899827] Update Tracker - [DefinedSet:5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - v67:[addCompartment]

Referrals

(updatedInstance)	[UpdateTracker:9899827] Update Tracker - [DefinedSet:5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] - v67:[addCompartment]
(input)	[Reaction:R-HSA-5362437] C-terminal Hh fragments are bound by lectins [Reaction:R-HSA-5362450] Hh processing variants bind lectins
(hasComponent)	[Complex:R-HSA-5362409] C-terminal Hh fragments:OS9/ERLEC1 [endoplasmic reticulum lumen] [Complex:R-HSA-5362408] ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] [Complex:R-HSA-5362380] SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] [Complex:R-HSA-5483237] ub-SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] [Complex:R-HSA-8866531] ERAD complex [endoplasmic reticulum membrane]
(output)	[Reaction:R-HSA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol [Reaction:R-HSA-5387389] Hh processing variants are translocated to the cytosol in a VCP-dependent manner

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