Reactome | VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol

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VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol Show undefined attributes

authored	[InstanceEdit:5359176] Rothfels, Karen, 2014-04-08
catalystActivity	[CatalystActivity:5362432] ABC-type transporter activity of ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5362458] Rothfels, Karen, 2014-04-15
dbId	5362459
displayName	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
edited	[InstanceEdit:5364056] D'Eustachio, Peter, 2014-04-19
eventOf	[Pathway:R-HSA-5358346] Hedgehog ligand biogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5362448] Hh C-terminal fragments are degraded by the proteasome - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 6 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-5362408] ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation [LiteratureReference:5359146] Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
orthologousEvent	[Reaction:R-DME-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Drosophila melanogaster [Reaction:R-GGA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Gallus gallus [Reaction:R-XTR-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Xenopus tropicalis [Reaction:R-DRE-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Danio rerio [Reaction:R-SSC-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Sus scrofa [Reaction:R-BTA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Bos taurus [Reaction:R-CFA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Canis familiaris [Reaction:R-RNO-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Rattus norvegicus [Reaction:R-MMU-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Mus musculus
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] 6 × [SimpleEntity:R-ALL-1132287] phosphate [cytoplasm] [Complex:R-HSA-5362378] SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] [CandidateSet:R-HSA-5362391] ub C-terminal Hh fragments [cytosol]
precedingEvent	[Reaction:R-HSA-5362412] SYVN1 ubiquitinates Hh C-terminal fragments - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5362459
summation	[Summation:5362456] The ATPase activity of VCP is required for the retrotransloc...

Referrals

(hasEvent)	[Pathway:R-HSA-5358346] Hedgehog ligand biogenesis
(precedingEvent)	[BlackBoxEvent:R-HSA-5362448] Hh C-terminal fragments are degraded by the proteasome