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Entries
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
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authored
[InstanceEdit:5359176] Rothfels, Karen, 2014-04-08
catalystActivity
[CatalystActivity:5362432] ABC-type transporter activity of ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5362458] Rothfels, Karen, 2014-04-15
dbId
5362459
displayName
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
edited
[InstanceEdit:5364056] D'Eustachio, Peter, 2014-04-19
eventOf
[Pathway:R-HSA-5358346] Hedgehog ligand biogenesis - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-5362448] Hh C-terminal fragments are degraded by the proteasome - Homo sapiens
input
6 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
6 ×
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[Complex:R-HSA-5362408] ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
[LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation
[LiteratureReference:5359146] Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum
modified
[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol
orthologousEvent
[Reaction:R-DME-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Drosophila melanogaster
[Reaction:R-GGA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Gallus gallus
[Reaction:R-XTR-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Xenopus tropicalis
[Reaction:R-DRE-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Danio rerio
[Reaction:R-SSC-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Sus scrofa
[Reaction:R-BTA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Bos taurus
[Reaction:R-CFA-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Canis familiaris
[Reaction:R-RNO-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Rattus norvegicus
[Reaction:R-MMU-5362459] VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol - Mus musculus
output
6 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[DefinedSet:R-HSA-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment]
6 ×
[SimpleEntity:R-ALL-1132287] phosphate [cytoplasm]
[Complex:R-HSA-5362378] SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
[CandidateSet:R-HSA-5362391] ub C-terminal Hh fragments [cytosol]
precedingEvent
[Reaction:R-HSA-5362412] SYVN1 ubiquitinates Hh C-terminal fragments - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5362459
summation
[Summation:5362456] The ATPase activity of VCP is required for the retrotransloc...
Referrals
(hasEvent)
[Pathway:R-HSA-5358346] Hedgehog ligand biogenesis
(precedingEvent)
[BlackBoxEvent:R-HSA-5362448] Hh C-terminal fragments are degraded by the proteasome
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