Reactome | ERAD complex [endoplasmic reticulum membrane]

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ERAD complex [endoplasmic reticulum membrane] Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane
componentOf	[Complex:R-HSA-8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - Homo sapiens [Complex:R-HSA-8866848] CFTR F508del:ERAD complex [endoplasmic reticulum membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation - Homo sapiens [Reaction:R-HSA-8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation - Homo sapiens [Reaction:R-HSA-9931313] p-S195-CD274 binds ERAD complex - Homo sapiens
created	[InstanceEdit:8866530] Rothfels, Karen, 2016-04-01
dbId	8866531
displayName	ERAD complex [endoplasmic reticulum membrane]
hasComponent	[Complex:R-HSA-8866529] DERL oligomer [endoplasmic reticulum membrane] [Complex:R-HSA-8866522] ERLIN1:ERLIN2 [endoplasmic reticulum membrane] [DefinedSet:R-HSA-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] [DefinedSet:R-HSA-8866527] RNF5,RNF185 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-1911545] SEL1L [endoplasmic reticulum membrane] [Complex:R-HSA-5362364] VCP hexamer [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:927893] endoplasmic reticulum quality control compartment
inferredTo	[Complex:R-MMU-8866531] ERAD complex [endoplasmic reticulum membrane] - Mus musculus [Complex:R-RNO-8866531] ERAD complex [endoplasmic reticulum membrane] - Rattus norvegicus [Complex:R-CFA-8866531] ERAD complex [endoplasmic reticulum membrane] - Canis familiaris [Complex:R-BTA-8866531] ERAD complex [endoplasmic reticulum membrane] - Bos taurus [Complex:R-SSC-8866531] ERAD complex [endoplasmic reticulum membrane] - Sus scrofa [Complex:R-DRE-8866531] ERAD complex [endoplasmic reticulum membrane] - Danio rerio [Complex:R-XTR-8866531] ERAD complex [endoplasmic reticulum membrane] - Xenopus tropicalis [Complex:R-GGA-8866531] ERAD complex [endoplasmic reticulum membrane] - Gallus gallus [Complex:R-DME-8866531] ERAD complex [endoplasmic reticulum membrane] - Drosophila melanogaster [Complex:R-CEL-8866531] ERAD complex [endoplasmic reticulum membrane] - Caenorhabditis elegans
isChimeric	false
maxDepth	4
modified	[InstanceEdit:8871616] Weiser, JD
name	ERAD complex
producedByEvent	[Reaction:R-HSA-8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol - Homo sapiens [Reaction:R-HSA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol - Homo sapiens [Reaction:R-HSA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8866531
updateTrackers	[UpdateTracker:9899818] Update Tracker - [Complex:8866531] ERAD complex [endoplasmic reticulum membrane] - v67:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9899818] Update Tracker - [Complex:8866531] ERAD complex [endoplasmic reticulum membrane] - v67:[updateContainedComponent]
(input)	[Reaction:R-HSA-8866857] CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation [Reaction:R-HSA-8866551] CFTR binds components of the ERAD machinery for ubiquitination and degradation [Reaction:R-HSA-9931313] p-S195-CD274 binds ERAD complex
(hasComponent)	[Complex:R-HSA-8866848] CFTR F508del:ERAD complex [endoplasmic reticulum membrane] [Complex:R-HSA-8866846] ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane] [Complex:R-HSA-8866538] misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] [Complex:R-HSA-8866535] Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] [Complex:R-HSA-9931263] p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]
(output)	[Reaction:R-HSA-8866854] VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol [Reaction:R-HSA-8866542] VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol [Reaction:R-HSA-9931264] Active transport of ubiquitinated CD274 from ER to cytosol
(activeUnit)	[CatalystActivity:9931282] ubiquitin protein ligase activity of p-S195-CD274:ERAD complex [endoplasmic reticulum membrane]

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