Reactome | Hh processing variants are translocated to the cytosol in a VCP-dependent manner

Schema > Reaction > Entries

Hh processing variants are translocated to the cytosol in a VCP-dependent manner Show undefined attributes

authored	[InstanceEdit:5359176] Rothfels, Karen, 2014-04-08
catalystActivity	[CatalystActivity:5387377] ABC-type transporter activity of ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5387388] Rothfels, Karen, 2014-04-29
dbId	5387389
disease	[Disease:5358398] holoprosencephaly
displayName	Hh processing variants are translocated to the cytosol in a VCP-dependent manner
edited	[InstanceEdit:5490367] D'Eustachio, Peter, 2014-05-19
entityFunctionalStatus	[EntityFunctionalStatus:9630078] gain_of_function of ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5387392] processing defective Hh variants are degraded by the proteasome - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] 6 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-5483239] ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation [LiteratureReference:5359146] Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh processing variants are translocated to the cytosol in a VCP-dependent manner
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] 6 × [SimpleEntity:R-ALL-1132287] phosphate [cytoplasm] [Complex:R-HSA-5362378] SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] [CandidateSet:R-HSA-5387369] ub-SHH variants [cytosol]
precedingEvent	[Reaction:R-HSA-5483238] Hh processing variants are ubiquitinated - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5387389
summation	[Summation:5387384] Depletion of the ATPase VCP results in the stabilization of ...

Referrals

(hasEvent)	[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD
(precedingEvent)	[BlackBoxEvent:R-HSA-5387392] processing defective Hh variants are degraded by the proteasome

Cite Us!