Reactome | Hh processing variants bind lectins

Schema > Reaction > Entries

Hh processing variants bind lectins Show undefined attributes

authored	[InstanceEdit:5358461] Rothfels, Karen, 2014-03-28
category	binding
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5362451] Rothfels, Karen, 2014-04-15
dbId	5362450
disease	[Disease:5358398] holoprosencephaly
displayName	Hh processing variants bind lectins
edited	[InstanceEdit:5490367] D'Eustachio, Peter, 2014-05-19
entityFunctionalStatus	[EntityFunctionalStatus:5362402] gain_of_function of SHH variants [endoplasmic reticulum lumen]
eventOf	[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD - Homo sapiens
followingEvent	[Reaction:R-HSA-5387386] Hh processing variants are recruited to SEL1:SYVN at the ER membrane - Homo sapiens
input	[DefinedSet:R-HSA-5362377] OS9/ERLEC1 [endoplasmic reticulum quality control compartment] [CandidateSet:R-HSA-5358456] SHH variants [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5359146] Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum [LiteratureReference:5358239] Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [LiteratureReference:5359171] One step at a time: endoplasmic reticulum-associated degradation [LiteratureReference:5359168] OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD [LiteratureReference:5359174] SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins [LiteratureReference:5359157] Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP [LiteratureReference:5359150] Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hh processing variants bind lectins
output	[Complex:R-HSA-5362380] SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen]
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5483156] Liu, Yulu Cherry, 2014-05-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5362450
summation	[Summation:5362795] Like the WT C-terminal fragment of Hh, processing-defective ...

Referrals

(hasEvent)	[Pathway:R-HSA-5362768] Hh mutants are degraded by ERAD
(precedingEvent)	[Reaction:R-HSA-5387386] Hh processing variants are recruited to SEL1:SYVN at the ER membrane