Reactome | Uptake and function of anthrax toxins

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Uptake and function of anthrax toxins Show undefined attributes

authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
created	[InstanceEdit:5210902] D'Eustachio, Peter, 2013-12-07
crossReference	[DatabaseIdentifier:12819497] BioModels Database:BIOMD0000000467 [DatabaseIdentifier:12020807] Mondo:0005119 [DatabaseIdentifier:12819463] BioModels Database:BIOMD0000000088 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468
dbId	5210891
disease	[Disease:5205706] anthrax disease
displayName	Uptake and function of anthrax toxins
doi	10.3180/REACT_228255.1
edited	[InstanceEdit:5490365] D'Eustachio, Peter, 2014-05-19
eventOf	[Pathway:R-HSA-5339562] Uptake and actions of bacterial toxins - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5210921] pagA binds ANTXR1 - Homo sapiens [Reaction:R-HSA-5210918] pagA binds ANTXR2 - Homo sapiens [Reaction:R-HSA-5210935] Furin cleaves ANTXR1-bound pagA to yield pagA(197-794) - Homo sapiens [Reaction:R-HSA-5210912] Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) - Homo sapiens [Reaction:R-HSA-9683546] FURIN binds furin inhibitors - Homo sapiens [Reaction:R-HSA-5210909] ANTXR1-bound pagA(197-794) forms oligomers - Homo sapiens [Reaction:R-HSA-5210932] ANTXR2-bound pagA(197-794) forms oligomers - Homo sapiens [Reaction:R-HSA-5210923] cya and lef bind to pagA(197-794):ANTXR1 oligomer - Homo sapiens [Reaction:R-HSA-5210892] cya and lef bind to pagA(197-794):ANTXR2 oligomer - Homo sapiens [BlackBoxEvent:R-HSA-5210944] Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) - Homo sapiens [BlackBoxEvent:R-HSA-5210959] Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) - Homo sapiens [BlackBoxEvent:R-HSA-5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens [BlackBoxEvent:R-HSA-5210943] pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens [Reaction:R-HSA-5211224] Anthrax cya catalyzes the conversion of ATP to cAMP - Homo sapiens [Reaction:R-HSA-5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) - Homo sapiens [Reaction:R-HSA-5211356] Anthrax lef cleaves target cell MAP2K2 (MEK2) - Homo sapiens [Reaction:R-HSA-5211400] Anthrax lef cleaves target cell MAP2K3 (MEK3) - Homo sapiens [Reaction:R-HSA-5211391] Anthrax lef cleaves target cell MAP2K4 (MEK4) - Homo sapiens [Reaction:R-HSA-5211405] Anthrax lef cleaves target cell MAP2K6 (MEK6) - Homo sapiens [Reaction:R-HSA-5211387] Anthrax lef cleaves target cell MAP2K7 (MEK7) - Homo sapiens
isInDisease	true
isInferred	false
lastUpdatedDate	2020-12-07
literatureReference	[LiteratureReference:5205733] Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins [LiteratureReference:5211331] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor [LiteratureReference:5211226] Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells [LiteratureReference:5212687] Manipulation of host signalling pathways by anthrax toxins [LiteratureReference:5211397] Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor [LiteratureReference:5205699] Anthrax toxin: receptor binding, internalization, pore formation, and translocation
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Uptake and function of anthrax toxins
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5210891
summation	[Summation:5210925] Bacillus anthracis bacteria target cells in an infected huma...
updateTrackers	[UpdateTracker:9776579] Update Tracker - [Pathway:5210891] Uptake and function of anthrax toxins - v75:[modifyText, updateContainedRLE] [UpdateTracker:9776758] Update Tracker - [Pathway:5210891] Uptake and function of anthrax toxins - v74:[addHasEvent, updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9776579] Update Tracker - [Pathway:5210891] Uptake and function of anthrax toxins - v75:[modifyText, updateContainedRLE] [UpdateTracker:9776758] Update Tracker - [Pathway:5210891] Uptake and function of anthrax toxins - v74:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5339562] Uptake and actions of bacterial toxins

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