Reactome | Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)

Schema > Reaction > Entries

Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) Show undefined attributes

authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
catalystActivity	[CatalystActivity:2159870] serine-type endopeptidase activity of FURIN [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5210902] D'Eustachio, Peter, 2013-12-07
crossReference	[DatabaseIdentifier:12020807] Mondo:0005119
dbId	5210912
disease	[Disease:5205706] anthrax disease
displayName	Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)
eventOf	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins - Homo sapiens
followingEvent	[Reaction:R-HSA-5210932] ANTXR2-bound pagA(197-794) forms oligomers - Homo sapiens
input	[Complex:R-HSA-5210007] pagA:ANTXR2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5205729] Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin [LiteratureReference:5205696] Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)
output	[Complex:R-HSA-5210020] pagA(197-794):ANTXR2 [plasma membrane] [EntityWithAccessionedSequence:R-BAN-5205700] pagA(30-196) [extracellular region]
precedingEvent	[Reaction:R-HSA-5210918] pagA binds ANTXR2 - Homo sapiens
regulatedBy	[NegativeRegulation:9691326] Negative regulation by 'FURIN:FURIN inhibitors [plasma membrane]'
regulationReference	[RegulationReference:9691327] Negative regulation by 'FURIN:FURIN inhibitors [plasma membrane]' Novel Furin Inhibitors with Potent Anti-infectious Activity
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5210912
summation	[Summation:5210931] Furin or a related protease at the cell surface cleaves ANTX...
updateTrackers	[UpdateTracker:9776879] Update Tracker - [Reaction:5210912] Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) - v74:[addRegulator] [UpdateTracker:9776501] Update Tracker - [Reaction:5210912] Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776879] Update Tracker - [Reaction:5210912] Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) - v74:[addRegulator] [UpdateTracker:9776501] Update Tracker - [Reaction:5210912] Furin cleaves ANTXR2-bound pagA to yield pagA(197-794) - v75:[modifyText]
(hasEvent)	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins
(precedingEvent)	[Reaction:R-HSA-5210932] ANTXR2-bound pagA(197-794) forms oligomers

Cite Us!