Reactome | cya and lef bind to pagA(197-794):ANTXR1 oligomer

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cya and lef bind to pagA(197-794):ANTXR1 oligomer Show undefined attributes

authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5210902] D'Eustachio, Peter, 2013-12-07
crossReference	[DatabaseIdentifier:12020807] Mondo:0005119
dbId	5210923
disease	[Disease:5205706] anthrax disease
displayName	cya and lef bind to pagA(197-794):ANTXR1 oligomer
eventOf	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5210944] Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-BAN-5205734] cya [extracellular region] 2 × [Complex:R-BAN-5211343] lef [extracellular region] [Complex:R-HSA-5210928] pagA(197-794):ANTXR1 oligomer [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5205727] Nucleotide sequence and analysis of the lethal factor gene (lef) from Bacillus anthracis [LiteratureReference:5210922] A quantitative study of the interactions of Bacillus anthracis edema factor and lethal factor with activated protective antigen [LiteratureReference:5211333] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity [LiteratureReference:5210901] Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously [LiteratureReference:5205695] Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	cya and lef bind to pagA(197-794):ANTXR1 oligomer
output	[Complex:R-HSA-5210915] cya:lef:(pagA(197-794):ANTXR1 oligomer) [plasma membrane]
precedingEvent	[Reaction:R-HSA-5210909] ANTXR1-bound pagA(197-794) forms oligomers - Homo sapiens
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5210923
summation	[Summation:5210913] The enzyme components of anthrax toxins cya (also known as E...
updateTrackers	[UpdateTracker:9776621] Update Tracker - [Reaction:5210923] cya and lef bind to pagA(197-794):ANTXR1 oligomer - v75:[modifyText]

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(updatedInstance)	[UpdateTracker:9776621] Update Tracker - [Reaction:5210923] cya and lef bind to pagA(197-794):ANTXR1 oligomer - v75:[modifyText]
(hasEvent)	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins
(precedingEvent)	[BlackBoxEvent:R-HSA-5210944] Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)