Reactome | pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)

Schema > BlackBoxEvent > Entries

pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) Show undefined attributes

authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
catalystActivity	[CatalystActivity:5210952] protein transmembrane transporter activity of cya:lef:(pagA(197-794):ANTXR1 oligomer) [endosome membrane]
category	omitted
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:5210945] D'Eustachio, Peter, 2013-12-07
crossReference	[DatabaseIdentifier:12020807] Mondo:0005119
dbId	5210947
disease	[Disease:5205706] anthrax disease
displayName	pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)
eventOf	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins - Homo sapiens
followingEvent	[Reaction:R-HSA-5211224] Anthrax cya catalyzes the conversion of ATP to cAMP - Homo sapiens [Reaction:R-HSA-5211387] Anthrax lef cleaves target cell MAP2K7 (MEK7) - Homo sapiens [Reaction:R-HSA-5211356] Anthrax lef cleaves target cell MAP2K2 (MEK2) - Homo sapiens [Reaction:R-HSA-5211391] Anthrax lef cleaves target cell MAP2K4 (MEK4) - Homo sapiens [Reaction:R-HSA-5211400] Anthrax lef cleaves target cell MAP2K3 (MEK3) - Homo sapiens [Reaction:R-HSA-5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) - Homo sapiens [Reaction:R-HSA-5211405] Anthrax lef cleaves target cell MAP2K6 (MEK6) - Homo sapiens
input	[Complex:R-HSA-5210940] cya:lef:(pagA(197-794):ANTXR1 oligomer) [endosome membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5567356] Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway [LiteratureReference:5212686] Anthrax protective antigen forms oligomers during intoxication of mammalian cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)
output	[EntityWithAccessionedSequence:R-BAN-5210957] cya [cytosol] [Complex:R-BAN-5211351] lef [cytosol] [Complex:R-HSA-5210946] pagA(197-794):ANTXR1 oligomer [endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-5210944] Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane) - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5210962] Positive regulation by 'H+ [endosome lumen]' [PositiveRegulation:R-HSA-5567361] Positive regulation by 'PDCD6IP [cytosol]'
regulationReference	[RegulationReference:9641947] Positive regulation by 'PDCD6IP [cytosol]' Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5210947
summation	[Summation:5210942] Through the action of vacuolar ATPase the pH of the target c...
updateTrackers	[UpdateTracker:9776623] Update Tracker - [BlackBoxEvent:5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776623] Update Tracker - [BlackBoxEvent:5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) - v75:[modifyText]
(precedingEvent)	[Reaction:R-HSA-5211224] Anthrax cya catalyzes the conversion of ATP to cAMP [Reaction:R-HSA-5211387] Anthrax lef cleaves target cell MAP2K7 (MEK7) [Reaction:R-HSA-5211356] Anthrax lef cleaves target cell MAP2K2 (MEK2) [Reaction:R-HSA-5211391] Anthrax lef cleaves target cell MAP2K4 (MEK4) [Reaction:R-HSA-5211400] Anthrax lef cleaves target cell MAP2K3 (MEK3) [Reaction:R-HSA-5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) [Reaction:R-HSA-5211405] Anthrax lef cleaves target cell MAP2K6 (MEK6)
(hasEvent)	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins