Reactome | Anthrax lef cleaves target cell MAP2K1 (MEK1)

Schema > Reaction > Entries

Anthrax lef cleaves target cell MAP2K1 (MEK1) Show undefined attributes

authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
catalystActivity	[CatalystActivity:5211347] metallopeptidase activity of lef [cytosol]
catalystActivityReference	[CatalystActivityReference:9643065] metallopeptidase activity of LF [cytosol] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5211335] D'Eustachio, Peter, 2013-12-09
crossReference	[DatabaseIdentifier:12020807] Mondo:0005119
dbId	5211340
disease	[Disease:5205706] anthrax disease
displayName	Anthrax lef cleaves target cell MAP2K1 (MEK1)
eventOf	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-59502] MAP2K1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5211331] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor [LiteratureReference:5211333] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity [LiteratureReference:5211349] Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Anthrax lef cleaves target cell MAP2K1 (MEK1)
output	[EntityWithAccessionedSequence:R-HSA-5211342] MAP2K1(2-8) [cytosol] [EntityWithAccessionedSequence:R-HSA-5211353] MAP2K1(9-393) [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens [BlackBoxEvent:R-HSA-5210943] pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5211340
summation	[Summation:5211355] lef (Anthrax LF, lethal factor), a zinc metalloprotease (Kli...
updateTrackers	[UpdateTracker:9776580] Update Tracker - [Reaction:5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776580] Update Tracker - [Reaction:5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) - v75:[modifyText]
(hasEvent)	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins

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