Reactome | Anthrax lef cleaves target cell MAP2K3 (MEK3)

Schema > Reaction > Entries

Anthrax lef cleaves target cell MAP2K3 (MEK3) Show undefined attributes

authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
catalystActivity	[CatalystActivity:5211347] metallopeptidase activity of lef [cytosol]
catalystActivityReference	[CatalystActivityReference:9643065] metallopeptidase activity of LF [cytosol] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5211386] D'Eustachio, Peter, 2013-12-10
crossReference	[DatabaseIdentifier:12020807] Mondo:0005119
dbId	5211400
disease	[Disease:5205706] anthrax disease
displayName	Anthrax lef cleaves target cell MAP2K3 (MEK3)
eventOf	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5211404] MAP2K3-3 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5211333] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity [LiteratureReference:5490363] Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Anthrax lef cleaves target cell MAP2K3 (MEK3)
output	[EntityWithAccessionedSequence:R-HSA-5211399] MAP2K3-3(1-26) [cytosol] [EntityWithAccessionedSequence:R-HSA-5211393] MAP2K3-3(27-347) [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens [BlackBoxEvent:R-HSA-5210943] pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5211400
summation	[Summation:5211403] lef (Anthrax LF, lethal factor) a zinc metalloprotease (Klim...
updateTrackers	[UpdateTracker:9776639] Update Tracker - [Reaction:5211400] Anthrax lef cleaves target cell MAP2K3 (MEK3) - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776639] Update Tracker - [Reaction:5211400] Anthrax lef cleaves target cell MAP2K3 (MEK3) - v75:[modifyText]
(hasEvent)	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins

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