Reactome | Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane)

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Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) Show undefined attributes

authored	[InstanceEdit:5212697] D'Eustachio, Peter, 2013-12-13
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:74700] endosome membrane
created	[InstanceEdit:5210945] D'Eustachio, Peter, 2013-12-07
crossReference	[DatabaseIdentifier:12020807] Mondo:0005119
dbId	5210959
disease	[Disease:5205706] anthrax disease
displayName	Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane)
eventOf	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5210943] pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens
input	[Complex:R-HSA-5210937] cya:lef:(pagA(197-794):ANTXR2 oligomer) [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5487064] Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process [LiteratureReference:5212278] EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin [LiteratureReference:5487077] Receptors of anthrax toxin and cell entry
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane)
output	[Complex:R-HSA-5210954] cya:lef:(pagA(197-794):ANTXR2 oligomer) [endosome membrane]
precedingEvent	[Reaction:R-HSA-5210892] cya and lef bind to pagA(197-794):ANTXR2 oligomer - Homo sapiens
relatedSpecies	[Species:5205709] Bacillus anthracis
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490366] Leppla, Stephen H, 2014-05-19 [InstanceEdit:5576992] Liu, Shihui, 2014-05-28 [InstanceEdit:5576994] Moayeri, Mahtab, 2014-05-28 [InstanceEdit:5567362] Turk, Benjamin E, 2014-05-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5210959
summation	[Summation:5210958] cya (Anthrax EF, edema factor) and lef (LF, lethal factor) t...
updateTrackers	[UpdateTracker:9776605] Update Tracker - [BlackBoxEvent:5210959] Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) - v75:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776605] Update Tracker - [BlackBoxEvent:5210959] Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane) - v75:[modifyText]
(precedingEvent)	[BlackBoxEvent:R-HSA-5210943] pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)
(hasEvent)	[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins

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