Reactome | TLE recruits HDAC1 to WNT promoters

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TLE recruits HDAC1 to WNT promoters Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4641232] Rothfels, K, 2013-09-27
dbId	4641231
displayName	TLE recruits HDAC1 to WNT promoters
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4641265] Repression of WNT target genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - Homo sapiens
inferredFrom	[Reaction:R-NUL-3299567] xTLE4 binds HDAC1 - Homo sapiens
input	[Complex:R-HSA-8944351] 'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-205021] HDAC1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:3299512] All Tcf HMG box transcription factors interact with Groucho-related co-repressors [LiteratureReference:3299508] A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development [LiteratureReference:4649033] The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription [LiteratureReference:4649018] Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TLE recruits HDAC1 to WNT promoters
output	[Complex:R-HSA-8944365] 'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4641231
summation	[Summation:4649022] Groucho/TLE mediates repression of WNT target genes in part ...
updateTrackers	[UpdateTracker:9782656] Update Tracker - [Reaction:4641231] TLE recruits HDAC1 to WNT promoters - v59:[add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9786108] Update Tracker - [Reaction:4641231] TLE recruits HDAC1 to WNT promoters - v50:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9782656] Update Tracker - [Reaction:4641231] TLE recruits HDAC1 to WNT promoters - v59:[add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9786108] Update Tracker - [Reaction:4641231] TLE recruits HDAC1 to WNT promoters - v50:[add_removeOutput]
(precedingEvent)	[BlackBoxEvent:R-HSA-5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
(hasEvent)	[Pathway:R-HSA-4641265] Repression of WNT target genes
(inferredTo)	[Reaction:R-NUL-3299567] xTLE4 binds HDAC1