Reactome | Repression of WNT target genes

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Repression of WNT target genes Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912706
displayName	Repression of WNT target genes
eventOf	[Pathway:R-DME-195253] Degradation of beta-catenin by the destruction complex - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-4641229] TLE oligomerizes - Drosophila melanogaster [Reaction:R-DME-8944349] TLE tetramers bind TCF/LEF at WNT promoters - Drosophila melanogaster [Reaction:R-DME-5334050] TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-4641265] Repression of WNT target genes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Repression of WNT target genes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-4641265
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-195253] Degradation of beta-catenin by the destruction complex
(inferredTo)	[Pathway:R-HSA-4641265] Repression of WNT target genes

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