Reactome | TLE oligomerizes

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TLE oligomerizes Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4641230] Rothfels, K, 2013-09-27
dbId	4641229
displayName	TLE oligomerizes
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4641265] Repression of WNT target genes - Homo sapiens
followingEvent	[Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters - Homo sapiens
input	4 × [DefinedSet:R-HSA-4649011] TLE [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3299512] All Tcf HMG box transcription factors interact with Groucho-related co-repressors [LiteratureReference:3299525] TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling [LiteratureReference:3299528] Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors [LiteratureReference:208367] Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation [LiteratureReference:3299509] A role for Groucho tetramerization in transcriptional repression [LiteratureReference:3299522] Groucho/TLE family proteins and transcriptional repression [LiteratureReference:3299508] A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development [LiteratureReference:3299523] Products of the grg (Groucho-related gene) family can dimerize through the amino-terminal Q domain [LiteratureReference:3299519] Groucho oligomerization is required for repression in vivo [LiteratureReference:3299517] Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	TLE oligomerizes
orthologousEvent	[Reaction:R-CEL-4641229] TLE oligomerizes - Caenorhabditis elegans [Reaction:R-DME-4641229] TLE oligomerizes - Drosophila melanogaster [Reaction:R-GGA-4641229] TLE oligomerizes - Gallus gallus [Reaction:R-XTR-4641229] TLE oligomerizes - Xenopus tropicalis [Reaction:R-DRE-4641229] TLE oligomerizes - Danio rerio [Reaction:R-SSC-4641229] TLE oligomerizes - Sus scrofa [Reaction:R-BTA-4641229] TLE oligomerizes - Bos taurus [Reaction:R-CFA-4641229] TLE oligomerizes - Canis familiaris [Reaction:R-RNO-4641229] TLE oligomerizes - Rattus norvegicus [Reaction:R-MMU-4641229] TLE oligomerizes - Mus musculus
output	[DefinedSet:R-HSA-3299565] TLE tetramer [nucleoplasm]
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4641229
summation	[Summation:4641226] TCF1, LEF1, TCF3 and TCF4 are HMG box-containing DNA-binding...
updateTrackers	[UpdateTracker:9782540] Update Tracker - [Reaction:4641229] TLE oligomerizes - v59:[add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782540] Update Tracker - [Reaction:4641229] TLE oligomerizes - v59:[add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-4641265] Repression of WNT target genes
(precedingEvent)	[Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters

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