Reactome | TCF/LEF binds WNT promoters

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TCF/LEF binds WNT promoters Show undefined attributes

authored	[InstanceEdit:8944135] Rothfels, Karen, 2016-11-03
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8944350] Rothfels, Karen, 2016-11-03
dbId	8944352
displayName	TCF/LEF binds WNT promoters
edited	[InstanceEdit:8944135] Rothfels, Karen, 2016-11-03
eventOf	[Pathway:R-HSA-4641265] Repression of WNT target genes - Homo sapiens
followingEvent	[Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters - Homo sapiens
input	[CandidateSet:R-HSA-4411390] 'canonical' WNT target genes [nucleoplasm] [CandidateSet:R-HSA-3299546] TCF/LEF [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3299525] TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling [LiteratureReference:3299528] Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors [LiteratureReference:3299512] All Tcf HMG box transcription factors interact with Groucho-related co-repressors [LiteratureReference:208367] Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation [LiteratureReference:3299517] Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression [LiteratureReference:3299508] A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development [LiteratureReference:3299522] Groucho/TLE family proteins and transcriptional repression
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TCF/LEF binds WNT promoters
output	[Complex:R-HSA-8944354] 'canonical' WNT target genes:TCF/LEF [nucleoplasm]
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8944352
summation	[Summation:8944355] TCF7 (TCF1), LEF1, TCF7L1 (TCF3) and TCF7L2 (TCF4) are HMG b...

Referrals

(hasEvent)	[Pathway:R-HSA-4641265] Repression of WNT target genes
(precedingEvent)	[Reaction:R-HSA-8944349] TLE tetramers bind TCF/LEF at WNT promoters