Reactome | Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes

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Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes Show undefined attributes

authored	[InstanceEdit:5228768] Rothfels, K, 2014-01-14
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5229349] Rothfels, K, 2014-01-17
dbId	5229348
displayName	Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
eventOf	[Pathway:R-HSA-4641265] Repression of WNT target genes - Homo sapiens
input	[CandidateSet:R-HSA-4411390] 'canonical' WNT target genes [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3238089] The way Wnt works: Components and mechanism [LiteratureReference:5229346] Context-dependent regulation of Groucho/TLE-mediated repression [LiteratureReference:5334041] The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines [LiteratureReference:5334038] TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription [LiteratureReference:5334036] A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes
output	[CandidateSet:R-HSA-4411358] 'canonical' WNT target gene transcripts [nucleoplasm]
precedingEvent	[Reaction:R-HSA-4641231] TLE recruits HDAC1 to WNT promoters - Homo sapiens [Reaction:R-HSA-5334050] TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-5229351] Negative gene expression regulation by ''canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-5339676] Negative gene expression regulation by 'TCF7L2/TCF7L1:CTBPs [nucleoplasm]'
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5229348
summation	[Summation:5229347] Transcription of WNT genes is repressed in the absence of WN...
updateTrackers	[UpdateTracker:9786170] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v50:[add_removeRegulator] [UpdateTracker:9782247] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v59:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9786170] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v50:[add_removeRegulator] [UpdateTracker:9782247] Update Tracker - [BlackBoxEvent:5229348] Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes - v59:[add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-4641265] Repression of WNT target genes