Reactome | Degradation of DVL

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Degradation of DVL Show undefined attributes

authored	[InstanceEdit:3772170] Rothfels, K, 2013-06-24
created	[InstanceEdit:4641259] Rothfels, K, 2013-09-27
dbId	4641258
displayName	Degradation of DVL
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02 [InstanceEdit:201675] Matthews, L, 2007-09-04 11:49:29
eventOf	[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:447849] negative regulation of canonical Wnt signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1504213] DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex - Homo sapiens [Reaction:R-HSA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Homo sapiens [BlackBoxEvent:R-HSA-1504193] Ubiquitinated DVL is degraded by the proteasome - Homo sapiens [Reaction:R-HSA-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Homo sapiens [Reaction:R-HSA-4641159] DVL1 is ubiquitinated by HECW1 - Homo sapiens [BlackBoxEvent:R-HSA-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Homo sapiens [Reaction:R-HSA-4641147] DACT1 binds DVL2 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3772339] Dishevelled: The hub of Wnt signaling [LiteratureReference:1504211] The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation [LiteratureReference:4641117] NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1 [LiteratureReference:4641100] Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation [LiteratureReference:4641101] Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation [LiteratureReference:4641107] The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	Degradation of DVL
orthologousEvent	[Pathway:R-DDI-4641258] Degradation of DVL - Dictyostelium discoideum [Pathway:R-CEL-4641258] Degradation of DVL - Caenorhabditis elegans [Pathway:R-DME-4641258] Degradation of DVL - Drosophila melanogaster [Pathway:R-GGA-4641258] Degradation of DVL - Gallus gallus [Pathway:R-XTR-4641258] Degradation of DVL - Xenopus tropicalis [Pathway:R-DRE-4641258] Degradation of DVL - Danio rerio [Pathway:R-SSC-4641258] Degradation of DVL - Sus scrofa [Pathway:R-BTA-4641258] Degradation of DVL - Bos taurus [Pathway:R-CFA-4641258] Degradation of DVL - Canis familiaris [Pathway:R-RNO-4641258] Degradation of DVL - Rattus norvegicus [Pathway:R-MMU-4641258] Degradation of DVL - Mus musculus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-4641258
summation	[Summation:4641150] DVL protein levels are regulated by both proteasomal and lys...

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[Pathway:R-HSA-201681] TCF dependent signaling in response to WNT

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