Reactome | Degradation of DVL

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Degradation of DVL Show undefined attributes

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649514
displayName	Degradation of DVL
eventOf	[Pathway:R-DRE-201681] TCF dependent signaling in response to WNT - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:447849] negative regulation of canonical Wnt signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-1504213] DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex - Danio rerio [Reaction:R-DRE-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Danio rerio [BlackBoxEvent:R-DRE-1504193] Ubiquitinated DVL is degraded by the proteasome - Danio rerio [Reaction:R-DRE-4641147] DACT1 binds DVL2 - Danio rerio
inferredFrom	[Pathway:R-HSA-4641258] Degradation of DVL - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Degradation of DVL
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-4641258
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-4641258] Degradation of DVL

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