Reactome | DVL is ubiquitinated by CUL3:KLHL12:RBX1

Schema > Reaction > Entries

DVL is ubiquitinated by CUL3:KLHL12:RBX1 Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:1504214] ubiquitin protein ligase activity of DVL:CUL3:KLHL12:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1504208] Rothfels, K, 2011-08-23
dbId	1504190
displayName	DVL is ubiquitinated by CUL3:KLHL12:RBX1
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641258] Degradation of DVL - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1504193] Ubiquitinated DVL is degraded by the proteasome - Homo sapiens
input	[Complex:R-HSA-1504210] DVL:CUL3:KLHL12:RBX1 [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1504211] The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DVL is ubiquitinated by CUL3:KLHL12:RBX1
negativePrecedingEvent	[NegativePrecedingEvent:9965530] Abundant Molecules: USP34 deubiquitinates AXIN1,AXIN2 [NegativePrecedingEvent:9965531] Abundant Molecules: USP8 deubiquitinates FZD to potentiate WNT signaling [NegativePrecedingEvent:9965533] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965512] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome [NegativePrecedingEvent:9965504] Abundant Molecules: Ubiquitinated DVL is degraded by the proteasome [NegativePrecedingEvent:9965536] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
orthologousEvent	[Reaction:R-PFA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Plasmodium falciparum [Reaction:R-DDI-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Dictyostelium discoideum [Reaction:R-CEL-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Caenorhabditis elegans [Reaction:R-DME-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Drosophila melanogaster [Reaction:R-GGA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Gallus gallus [Reaction:R-XTR-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Xenopus tropicalis [Reaction:R-DRE-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Danio rerio [Reaction:R-SSC-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Sus scrofa [Reaction:R-BTA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Bos taurus [Reaction:R-RNO-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Rattus norvegicus [Reaction:R-MMU-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Mus musculus
output	[Complex:R-HSA-4652690] ub-DVL:CUL3:KLHL12:RBX1 [cytosol]
precedingEvent	[Reaction:R-HSA-1504213] DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1504190
summation	[Summation:1504191] CUL3:KLHL12:RBX1 polyubiquitinates Dishevelled, targeting it...

Referrals

(hasEvent)	[Pathway:R-HSA-4641258] Degradation of DVL
(precedingEvent)	[BlackBoxEvent:R-HSA-1504193] Ubiquitinated DVL is degraded by the proteasome

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