Reactome | Ubiquitinated DVL1 is degraded by the proteasome

Schema > BlackBoxEvent > Entries

Ubiquitinated DVL1 is degraded by the proteasome Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4641259] Rothfels, K, 2013-09-27
dbId	4641260
displayName	Ubiquitinated DVL1 is degraded by the proteasome
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641258] Degradation of DVL - Homo sapiens
input	[Complex:R-HSA-4641160] ub-DVL1:HECW1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4641117] NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Ubiquitinated DVL1 is degraded by the proteasome
orthologousEvent	[BlackBoxEvent:R-CEL-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Caenorhabditis elegans [BlackBoxEvent:R-DME-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Drosophila melanogaster [BlackBoxEvent:R-GGA-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Gallus gallus [BlackBoxEvent:R-SSC-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Sus scrofa [BlackBoxEvent:R-BTA-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Bos taurus [BlackBoxEvent:R-CFA-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Canis familiaris [BlackBoxEvent:R-RNO-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Rattus norvegicus [BlackBoxEvent:R-MMU-4641260] Ubiquitinated DVL1 is degraded by the proteasome - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-4641156] HECW1 [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-4641159] DVL1 is ubiquitinated by HECW1 - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-4641260
summation	[Summation:4641141] After ubiquitination by HECW1, DVL1 is degraded by the prote...

Referrals

(hasEvent)

[Pathway:R-HSA-4641258] Degradation of DVL

(precedingEvent)

[NegativePrecedingEvent:9965522] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
[NegativePrecedingEvent:9965507] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
[NegativePrecedingEvent:9965523] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
[NegativePrecedingEvent:9965536] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
[NegativePrecedingEvent:9965505] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
[NegativePrecedingEvent:9965529] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
[NegativePrecedingEvent:9965544] Futile Cycle: Ubiquitinated DVL1 is degraded by the proteasome