Reactome | DVL1 is bound by the HECT ubiquitin ligase HECW1

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DVL1 is bound by the HECT ubiquitin ligase HECW1 Show undefined attributes

authored	[InstanceEdit:4610796] Rothfels, K, 2013-09-23
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4641152] Rothfels, K, 2013-09-27
dbId	4641155
displayName	DVL1 is bound by the HECT ubiquitin ligase HECW1
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-4641258] Degradation of DVL - Homo sapiens
followingEvent	[Reaction:R-HSA-4641159] DVL1 is ubiquitinated by HECW1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-201687] DVL1 [cytosol] [EntityWithAccessionedSequence:R-HSA-4641156] HECW1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4641117] NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	DVL1 is bound by the HECT ubiquitin ligase HECW1
negativePrecedingEvent	[NegativePrecedingEvent:9965544] Futile Cycle: Ubiquitinated DVL1 is degraded by the proteasome
orthologousEvent	[Reaction:R-CEL-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Caenorhabditis elegans [Reaction:R-DME-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Drosophila melanogaster [Reaction:R-GGA-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Gallus gallus [Reaction:R-SSC-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Sus scrofa [Reaction:R-BTA-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Bos taurus [Reaction:R-CFA-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Canis familiaris [Reaction:R-RNO-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Rattus norvegicus [Reaction:R-MMU-4641155] DVL1 is bound by the HECT ubiquitin ligase HECW1 - Mus musculus
output	[Complex:R-HSA-4641154] DVL1:HECW1 [cytosol]
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4641155
summation	[Summation:4641153] HECW1, also known as NEDL1, is an HECT E3 ligase that co-imm...

Referrals

(hasEvent)	[Pathway:R-HSA-4641258] Degradation of DVL
(precedingEvent)	[Reaction:R-HSA-4641159] DVL1 is ubiquitinated by HECW1

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