Degradation of DVL

Stable Identifier
Homo sapiens
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DVL protein levels are regulated by both proteasomal and lysosomal degradation (reviewed in Gao and Chen, 2010). The E3 ligases HECF1, ITCH and KLHL12:CUL3 have all been shown to contribute to the polyubiquitination and subsequent degradation of DVL (Angers et al, 2006; Miyazaki et al, 2004; Wei et al, 2012). DVL stability is also regulated by its interaction with DACT1, which promotes degradation of DVL in the lysosome (Cheyette et al, 2002; Zhang et al, 2006).

Literature References
PubMed ID Title Journal Year
16446366 Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation

Chen, YG, Ning, Y, Zhang, L, Wen, J, Gao, X

J. Biol. Chem. 2006
14684739 NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1

Miyazaki, K, Aoki, M, Itoyama, Y, Ozaki, T, Goto, T, Kurose, Y, Fujita, T, Kato, S, Kato, C, Nakagawara, A, Sakamoto, M

J. Biol. Chem. 2004
11970895 Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation

Waxman, JS, Fox, EP, Khlebtsova, N, Sheldahl, LC, Cheyette, BN, Takemaru, K, Miller, JR, Moon, RT, Earnest, T

Dev. Cell 2002
20006983 Dishevelled: The hub of Wnt signaling

Chen, YG, Gao, C

Cell. Signal. 2010
22826439 The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein

Li, L, Nie, F, Wang, J, Li, M, Wei, W

Mol. Cell. Biol. 2012
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Maccoss, MJ, Biechele, TL, Thorpe, CJ, Zheng, N, Angers, S, Goldenberg, SJ, Moon, RT

Nat Cell Biol 2006
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Orthologous Events
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