Reactome | Degradation of DVL

Schema > Pathway > Entries

created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11128814
displayName	Degradation of DVL
eventOf	[Pathway:R-PFA-201681] TCF dependent signaling in response to WNT - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:447849] negative regulation of canonical Wnt signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-PFA-1504190] DVL is ubiquitinated by CUL3:KLHL12:RBX1 - Plasmodium falciparum [BlackBoxEvent:R-PFA-1504193] Ubiquitinated DVL is degraded by the proteasome - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-4641258] Degradation of DVL - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Degradation of DVL
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-4641258
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-PFA-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-4641258] Degradation of DVL